首页> 外文OA文献 >Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

【2h】

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

机译：整合素αvβ6（潜在的转化生长因子-β的激活剂）的抑制作用可预防辐射诱发的肺纤维化

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Rationale: In experimental models, lung fibrosis is dependent on transforming growth factor (TGF)-β signaling. TGF-β is secreted in a latent complex with its propeptide, and TGF-β activators release TGF-β from this complex. Because the integrin αvβ6 is a major TGF-β activator in the lung, inhibition of αvβ6-mediated TGF-β activation is a logical strategy to treat lung fibrosis.

机译：原理：在实验模型中，肺纤维化取决于转化生长因子（TGF）-β信号传导。 TGF-β与其前肽一起潜伏在复合物中，而TGF-β激活剂则从该复合物中释放TGF-β。由于整联蛋白αvβ6是肺中主要的TGF-β激活剂，因此抑制αvβ6介导的TGF-β激活是治疗肺纤维化的合理策略。

著录项

作者
Puthawala, Khalid; Hadjiangelis, Nicos; Jacoby, Steven C.; Bayongan, Emmanuel; Zhao, Zhicheng; Yang, Zhiwei; Devitt, Mary Louise; Horan, Gerald S.; Weinreb, Paul H.; Lukashev, Matvey E.; Violette, Shelia M.; Grant, Kristen S.; Colarossi, Cristina; Formenti, Silvia C.; Munger, John S.;
展开▼
作者单位

展开▼
年度 2008
总页数
原文格式 PDF
正文语种 en
中图分类

相似文献

外文文献
中文文献
专利

1. Thy-1-Integrin αvβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation [J] . Yong Zhou, James S. Hagood, Baogen Lu, The Journal of biological chemistry . 2010,第29期

机译：Thy-1-结合蛋白αvβ5相互作用抑制肺成纤维细胞收缩诱导的潜在转化生长因子-β1活化和肌纤维细胞分化
2. Latent Transforming Growth Factor-β Binding Protein-1, a Component of Latent Transforming Growth Factor-β Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-β_3 [J] . Tetsuto Kanzaki, Masako Otabe Diabetes . 2003,第3期

机译：潜在转化生长因子-β复合物的组成部分潜在转化生长因子-β结合蛋白-1通过整合素-β_3促进糖尿病大鼠主动脉平滑肌细胞的迁移。
3. Latent Transforming Growth Factor-{beta}-Binding Protein-4 Regulates Transforming Growth Factor-{beta}1 Bioavailability for Activation by Fibrogenic Lung Fibroblasts in Response to Bleomycin [J] . Yong Zhou, Katri Koli, James S. Hagood, American Journal of Pathology . 2009,第1期

机译：潜在的转化生长因子-β-结合蛋白4调节转化生长因子-β1生物利用度对博来霉素的激活作用由纤维化肺成纤维细胞激活。
4. Potential Role of Glyceollin as Anti-Metastatic Agent through Transforming Growth Factor-β Receptors Inhibition Signaling Pathways: A Computational Study [C] . Feri Eko Hermanto, Muhaimin Rifai, Widodo International Conference on Biosciences and Medical Engineering . 2019

机译：Glyceollin作为抗转移剂通过转化生长因子-β受体抑制信号通路的潜在作用：计算研究
5. Integrin activation of latent transforming growth factor-beta. [D] . Aluwihare, Poshala. 2009

机译：整合素激活潜在的转化生长因子-β。
6. Inhibition of Integrin αvβ6 an Activator of Latent Transforming Growth Factor-β Prevents Radiation-induced Lung Fibrosis [O] . Khalid Puthawala, Nicos Hadjiangelis, Steven C. Jacoby, -1

机译：整合素αvβ6（潜在的转化生长因子-β的激活剂）的抑制作用可预防辐射诱发的肺纤维化
7. Thy-1-Integrin αvβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation* [O] . Zhou, Yong, Hagood, James S., Lu, Baogen, 2010

机译：Thy-1-整合素αvβ5相互作用抑制肺成纤维细胞收缩诱导的潜在转化生长因子-β1活化和成肌纤维细胞分化*

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

摘要

著录项

相似文献

相关主题

期刊订阅